Knowledge

Supplements

The supplement shop sells hundreds of tubs and bottles, but only a handful have an effect in athletes that has actually been demonstrated. Below are 40 supplements covering what they do, how much you need, when to take them and what to watch out for — ranked by how solid the evidence is, not by how loudly they're marketed.

Short answer

Don't feel like reading the whole list? For most people who train, three supplements are worth it, as long as your basics are in place.

  • Creatine for strength and muscle mass
  • Caffeine for alertness and performance
  • Vitamin D when sunlight is scarce, especially in winter

40 of 40 supplements

All supplements at a glance

Basics first, then the tub

Supplements are called supplements because they add to something. Sleep, a protein intake that hits your protein calculator , a programme where you lift progressively heavier and enough food together do a hundred times more than the best-researched item on this list. Once those are in place, creatine, caffeine and vitamin D in winter are the three you can spend money on with a clear conscience — for less than ten euros a month combined.

Purity and doping

Supplements are food products, not medicines: nobody checks beforehand that what's on the label is actually in the container. Spot checks regularly find undeclared stimulants or hormones, especially in pre-workouts and fat burners. If you're subject to doping controls, only buy products with a certification that tests every batch, such as Informed Sport or NZVT.

Frequently asked questions about supplements

Which supplements actually work?

For athletes, the evidence is strongest for creatine (strength and muscle mass) and caffeine (performance and alertness). Vitamin D can make sense if you get little sun, for example in winter. The rest of the list has less or weaker evidence; the label on each supplement shows which.

Do I need supplements as a beginner?

No. Sleep, enough protein, enough food and a programme where you lift a little heavier step by step do far more than any tub. Supplements at most top up that foundation.

When is the best time to take creatine?

The time of day matters little. What matters more is taking it daily so your muscles stay saturated. The usual dose of creatine monohydrate is 3 to 5 grams per day.

Are supplements safe?

The best-researched supplements are generally safe for healthy adults at normal doses. Purity is not guaranteed, though, because supplements aren't checked in advance the way medicines are. If you take medication, are pregnant or have a medical condition, talk to your doctor or pharmacist first.

What does a sensible basic stack cost?

Creatine, caffeine and vitamin D usually cost less than ten euros a month combined. Expensive blends with many ingredients often contain too little of each one to have any effect.

How this page was made

The evidence label on each supplement is based on research in humans, giving the most weight to systematic reviews and position stands from sports nutrition organisations such as the International Society of Sports Nutrition. One striking study or a social media story is not enough for the label strong.

Last updated: October 2026

Sources

These are the main sources behind the evidence labels, doses and warnings on this page.

Casein

  • Trommelen J et al. (2023). Pre-sleep protein ingestion increases mitochondrial protein synthesis rates during overnight recovery from endurance exercise: a randomized controlled trial. Sports Med. (randomized trial, n = 36)

Plant protein

  • Messina M et al. (2018). No difference between the effects of supplementing with soy protein versus animal protein on gains in muscle mass and strength in response to resistance exercise. Int J Sport Nutr Exerc Metab. (meta-analysis, 9 studies, n = 266)
  • Effect of plant versus animal protein on muscle mass, strength, physical performance, and sarcopenia: a systematic review and meta-analysis of randomized controlled trials (2025). Nutr Rev. (meta-analysis)

Carbohydrate powder

  • Jeukendrup A (2014). A step towards personalized sports nutrition: carbohydrate intake during exercise. Sports Med 44(Suppl 1):S25-S33. (review)

Electrolytes

  • Hew-Butler T et al. (2015). Statement of the 3rd International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015. Clin J Sport Med. (consensus statement)

L-theanine

  • Camfield DA et al. (2014). Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. Nutr Rev. (meta-analysis, 11 studies)

Multivitamins

  • O Connor EA et al. (2022). Vitamin and mineral supplements for the primary prevention of cardiovascular disease and cancer: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA 327(23):2334-2347. (systematic review)
  • Sesso HD et al. (2012). Multivitamins in the prevention of cardiovascular disease in men: the Physicians Health Study II randomized controlled trial. JAMA 308(17):1751-1760. (randomized trial, n = 14,641)
  • Gaziano JM et al. (2012). Multivitamins in the prevention of cancer in men: the Physicians Health Study II randomized controlled trial. JAMA 308(18):1871-1880. (randomized trial, n = 14,641)
  • Loftfield E et al. (2024). Multivitamin use and mortality risk in 3 prospective US cohorts. JAMA Netw Open. (cohort study, n = 390,124)

Glutamine

  • Ramezani Ahmadi A et al. (2019). The effect of glutamine supplementation on athletic performance, body composition, and immune function: a systematic review and a meta-analysis of clinical trials. Clin Nutr. (meta-analysis, 25 trials)
  • Street B, Byrne C, Eston R (2011). Glutamine supplementation in recovery from eccentric exercise attenuates strength loss and muscle soreness. J Exerc Sci Fit. (small trial)

Taurine

  • Waldron M et al. (2018). The effects of an oral taurine dose and supplementation period on endurance exercise performance in humans: a meta-analysis. Sports Med. (meta-analysis)
  • Does one shot work? The acute impact of a single taurine dose on exercise performance: a meta-analytic review (2025). (meta-analysis)

ZMA

  • Wilborn CD et al. (2004). Effects of zinc magnesium aspartate (ZMA) supplementation on training adaptations and markers of anabolism and catabolism. J Int Soc Sports Nutr 1(2):12-20. (randomized trial)
  • Brilla LR, Conte V (2000). Effects of a novel zinc-magnesium formulation on hormones and strength. J Exerc Physiol Online. (small trial in football players)

Probiotics

  • Jäger R et al. (2019). International Society of Sports Nutrition position stand: probiotics. J Int Soc Sports Nutr 16:62. (position stand)

Ketone esters

  • Valenzuela PL et al. (2020). Acute ketone supplementation and exercise performance: a systematic review and meta-analysis of randomized controlled trials. Int J Sports Physiol Perform 15(3):298-308. (meta-analysis)

Creatine

  • Kreider RB et al. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr 14:18. (position stand)

Whey (protein needs)

  • Jäger R et al. (2017). International Society of Sports Nutrition position stand: protein and exercise. J Int Soc Sports Nutr 14:20. (position stand)

Caffeine

  • Guest NS et al. (2021). International society of sports nutrition position stand: caffeine and exercise performance. J Int Soc Sports Nutr 18:1. (position stand)

Beta-alanine

  • Trexler ET et al. (2015). International Society of Sports Nutrition position stand: Beta-Alanine. J Int Soc Sports Nutr 12:30. (position stand)

Sodium bicarbonate

  • Grgic J et al. (2021). International Society of Sports Nutrition position stand: sodium bicarbonate and exercise performance. J Int Soc Sports Nutr 18:61. (position stand)

Citrulline malate

  • Vårvik FT et al. (2021). Acute effect of citrulline malate on repetition performance during strength training: a systematic review and meta-analysis. (meta-analysis, 8 studies)

Beetroot juice (nitrate)

  • Australian Institute of Sport. Sports Supplement Framework: dietary nitrate / beetroot juice. (fact sheet)
  • Effects of beetroot juice on physical performance in professional athletes and healthy individuals: an umbrella review (2025). Nutrients. (umbrella review of 15 meta-analyses)

HMB

  • Wilson JM et al. (2013). International Society of Sports Nutrition position stand: beta-hydroxy-beta-methylbutyrate (HMB). J Int Soc Sports Nutr 10:6. (position stand)
  • Sanchez-Martinez J et al. (2018). Effects of HMB supplementation on strength and body composition of trained and competitive athletes: a meta-analysis of randomized controlled trials. J Sci Med Sport. (meta-analysis)

BCAA

  • Wolfe RR (2017). Branched-chain amino acids and muscle protein synthesis in humans: myth or reality? J Int Soc Sports Nutr 14:30. (review)

Testosterone boosters

  • Qureshi A et al. (2014). A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. J Diet Suppl 11(1):64-79. (systematic review)
  • Effects of Tribulus (Tribulus terrestris L.) supplementation on erectile dysfunction and testosterone levels in men: a systematic review of clinical trials (2025). Nutrients 17(7):1275. (systematic review)
  • Willoughby DS, Leutholtz B (2013). D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones in resistance-trained men. Nutr Res 33(10):803-810. (randomized trial, n = 20)
  • Melville GW et al. (2015). Three and six grams supplementation of d-aspartic acid in resistance trained men. J Int Soc Sports Nutr. (randomized trial)

Omega-3

  • EFSA (2012). Scientific opinion related to the tolerable upper intake level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA). EFSA Journal 10(7):2815. (regulatory opinion)

Collagen with vitamin C

  • Shaw G et al. (2017). Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. Am J Clin Nutr 105(1):136-143. (small randomized crossover trial)
  • Praet SFE et al. (2019). Oral supplementation of specific collagen peptides combined with calf-strengthening exercises enhances function and reduces pain in Achilles tendinopathy patients. Nutrients 11(1):76. (small randomized trial)

Glucosamine and chondroitin

  • Clegg DO et al. (2006). Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354:795-808. (GAIT trial, n = 1583)

Curcumin

  • The effect of curcumin supplementation on delayed-onset muscle soreness, inflammation, muscle strength, and joint flexibility: a systematic review and dose-response meta-analysis of randomized controlled trials (2022). Phytother Res 36(7):2767-2778. (meta-analysis, 10 trials)
  • Liu X, Lin L, Hu G (2024). Meta-analysis of the effect of curcumin supplementation on skeletal muscle damage status. PLoS ONE 19(7):e0299135. (meta-analysis, 14 studies)

Tart cherry

  • Hill JA et al. (2021). Tart cherry supplementation and recovery from strenuous exercise: a systematic review and meta-analysis. (meta-analysis, 14 studies)

Vitamin D3

  • Hoge Gezondheidsraad (België): advies vitamine D voor volwassenen, 10 µg per dag in de wintermaanden. (official advice)
  • EFSA (2012). Scientific opinion on the tolerable upper intake level of vitamin D. EFSA Journal 10(7):2813. (regulatory opinion)

Magnesium

  • Garrison SR et al. (2020). Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev CD009402. (Cochrane review)
  • The role of magnesium in sleep health: a systematic review of available literature (2022). (systematic review)

Iron

  • Stoffel NU et al. (2017). Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women. Lancet Haematol 4(11):e524-e533. (randomized trial, n = 40)

Vitamin B12

  • The Vegan Society / VeganHealth.org: what every vegan should know about vitamin B12. (guidance from a vegan organisation)

Zinc

  • Nault D et al. (2024). Zinc for prevention and treatment of the common cold. Cochrane Database Syst Rev CD014914. (Cochrane review)
  • Hemilä H, Chalker E (2024). Shortcomings in the Cochrane review on zinc for the common cold (2024). Front Med 11:1470004. (re-analysis)
  • EFSA (2024). Summary of tolerable upper intake levels (UL summary report). (regulatory report)

High-dose vitamin C

  • Hemilä H, Chalker E (2013). Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev CD000980. (Cochrane review)
  • Paulsen G et al. (2014). Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial. J Physiol 592(8):1887-1901. (randomized trial)

Melatonin

  • Herxheimer A, Petrie KJ (2002). Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev CD001520. (Cochrane review, 10 trials)

Ashwagandha

  • MSD Manual, professional version: Ashwagandha. (reference text summarising meta-analyses and safety reports)

Glycine

  • Bannai M et al. (2012). The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol 3:61. (small randomized crossover trial, n = 7)
  • Yamadera W et al. (2007). Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep Biol Rhythms. (small trial)

Green tea extract

  • Jurgens TM et al. (2012). Green tea for weight loss and weight maintenance in overweight or obese adults. Cochrane Database Syst Rev CD008650. (Cochrane review)
  • EFSA Panel on Food Additives and Nutrient Sources (2018). Scientific opinion on the safety of green tea catechins. EFSA Journal 16(4):5239. (regulatory opinion)

L-carnitine

  • Pooyandjoo M et al. (2016). The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. (meta-analysis)
  • Wall BT et al. (2011). Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol 589:963-973. (randomized trial)

CLA

  • Whigham LD et al. (2007). Efficacy of free fatty acid conjugated linoleic acid supplementation on body composition: a meta-analysis. Am J Clin Nutr 85(5):1203-1211. (meta-analysis)
  • Onakpoya IJ et al. (2012). The efficacy of long-term conjugated linoleic acid supplementation on body composition in overweight and obese individuals: a systematic review and meta-analysis of randomized clinical trials. Eur J Nutr 51:127-134. (meta-analysis)

Raspberry ketones and garcinia

  • Onakpoya I et al. (2011). The use of Garcinia extract (hydroxycitric acid) as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials. J Obes 2011:509038. (meta-analysis)
  • NIH National Center for Complementary and Integrative Health (NCCIH): Garcinia cambogia. (fact sheet)

This page summarises scientific research and is not medical advice. If you take medication, are pregnant or have a liver, kidney or thyroid condition, discuss supplements with your doctor or pharmacist — even the innocent-looking ones.